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KMID : 0364019740070010001
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Korean Journal of Thoracic and Cardiovascular Surgery
1974 Volume.7 No. 1 p.1 ~ p.8
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Experimental Study of Surface Activity in Acute Pulmonary Edema
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Abstract
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Acute pulmonary edema was induced by intravenous injection of epinephrine, initravenous infusion of dextran and intratracheal instillation of acid solution index was determined from pressure volume curves in excised lungs. Surface activity was also investigated with measurments of maximum and minimum surface tension and stability index on saline extracts of same lungs.
The results were as follows.
1. The expansion index of excised lung in which pulmonary edema was induced by intravenous injection of epinephrine, intravenous infusion of dextran and intratracheal instillation of acid osiution was significantly decreased as compared with the normal control of 0.86±0.017 to 0.74±0.03, 0.71±0.081 and 0.76±0.02, respectively.
2. The deflation curves of excised lungs in which pulmonary edema was induced were significantly decreased as compared with the normal controls.
3. The minimum surface tension of excised lung in which pulmonary edema was induced was significantly increased in each groups and stability index was signicantly decreased as compared with the normal controls 0.78 to 0.35±0.039, 0.29±0.02 and 0.31±0.083, respecively.
4. The decrease of pulmonary surface activity in acute pulmonary edema was in proportion to the degree of pulmonary edema regardless of their etiology.
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